Publication: Lack of APP and APLP2 in GABAergic Forebrain Neurons Impairs Synaptic Plasticity and Cognition
Lack of APP and APLP2 in GABAergic Forebrain Neurons Impairs Synaptic Plasticity and Cognition
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Mehr, A., Hick, M., Ludewig, S., Müller, M., Herrmann, U., von Engelhardt, J., Wolfer, D. P., Korte, M., & Müller, U. C. (2020). Lack of APP and APLP2 in GABAergic Forebrain Neurons Impairs Synaptic Plasticity and Cognition. Cerebral Cortex, 30, 4044–4063. https://doi.org/10.1093/cercor/bhaa025
Abstract
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Abstract
Amyloid-β precursor protein (APP) is central to the pathogenesis of Alzheimer’s disease, yet its physiological functions remain incompletely understood. Previous studies had indicated important synaptic functions of APP and the closely related homologue APLP2 in excitatory forebrain neurons for spine density, synaptic plasticity, and behavior. Here, we show that APP is also widely expressed in several interneuron subtypes, both in hippocampus and cortex. To address the functional role of APP in inhibitory neurons, we generated mice wi
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- Mehr, Annika
- Hick, Meike
- Ludewig, Susann
- Müller, Michaela
- Herrmann, Ulrike
- von Engelhardt, Jakob
- Wolfer, David P
- Korte, Martin
- Müller, Ulrike C
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Citations
Mehr, A., Hick, M., Ludewig, S., Müller, M., Herrmann, U., von Engelhardt, J., Wolfer, D. P., Korte, M., & Müller, U. C. (2020). Lack of APP and APLP2 in GABAergic Forebrain Neurons Impairs Synaptic Plasticity and Cognition. Cerebral Cortex, 30, 4044–4063. https://doi.org/10.1093/cercor/bhaa025
