Publication: Mitochondria in chronic liver disease
Mitochondria in chronic liver disease
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Grattagliano, I., Russmann, S., Diogo, C. V., Bonfrate, L., Oliveira, P. J., Wang, D. Q. H., & Portincasa, P. (2011). Mitochondria in chronic liver disease. Current Drug Targets, 12, 879–893. https://doi.org/10.2174/138945011795528877
Abstract
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Mitochondria are the main energy source in hepatocytes and play a major role in extensive oxidative metabolism and normal function of the liver. This key role also assigns mitochondria a gateway function in the center of signaling pathways that mediate hepatocyte injury, because impaired mitochondrial functions affect cell survival and contribute to the onset and perpetuation of liver diseases. Altered mitochondrial functions have indeed been documented in a variety of chronic liver diseases including alcohol-induced liver disease, no
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- Grattagliano, I
- Russmann, S
- Bonfrate, L
- Oliveira, P J
- Wang, D Q H
- Portincasa, P
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Grattagliano, I., Russmann, S., Diogo, C. V., Bonfrate, L., Oliveira, P. J., Wang, D. Q. H., & Portincasa, P. (2011). Mitochondria in chronic liver disease. Current Drug Targets, 12, 879–893. https://doi.org/10.2174/138945011795528877