Publication: Tracking prions: the neurografting approach.
Tracking prions: the neurografting approach.
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Aguzzi, A., Blättler, T., Klein, M. A., Räber, A. J., Hegyi, I., Frigg, R., Brandner, S., & Weissmann, C. (1997). Tracking prions: the neurografting approach. Cellular and Molecular Life Sciences, 53(6), 485–495. https://doi.org/10.1007/s000180050060
Abstract
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The physical nature of the agent that causes transmissible spongiform encephalopathies (the 'prion'), is the subject of passionate controversy. Investigation of it has benefited tremendously from the use of transgenic and knockout technologies. However, prion diseases present several other enigmas, including the mechanism of brain damage and how the affinity of the agent for the central nervous system is controlled. Here we show that such questions can be effectively addressed in transgenic and knockout systems, and that pathogenesis
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- Blättler, T
- Klein, M A
- Räber, A J
- Hegyi, I
- Frigg, R
- Brandner, S
- Weissmann, C
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Aguzzi, A., Blättler, T., Klein, M. A., Räber, A. J., Hegyi, I., Frigg, R., Brandner, S., & Weissmann, C. (1997). Tracking prions: the neurografting approach. Cellular and Molecular Life Sciences, 53(6), 485–495. https://doi.org/10.1007/s000180050060