Publication: Hyperantithrombotic, noncytoprotective Glu149Ala-activated protein C mutant
Hyperantithrombotic, noncytoprotective Glu149Ala-activated protein C mutant
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Mosnier, L. O., Zampolli, A., Kerschen, E. J., Schuepbach, R. A., Banerjee, Y., Fernández, J. A., Yang, X. V., Riewald, M., Weiler, H., Ruggeri, Z. M., & Griffin, J. H. (2009). Hyperantithrombotic, noncytoprotective Glu149Ala-activated protein C mutant. Blood, 113(23), 5970–5978. https://doi.org/10.1182/blood-2008-10-183327
Abstract
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Activated protein C (APC) reduces mortality in severe sepsis patients. APC exerts anticoagulant activities via inactivation of factors Va and VIIIa and cytoprotective activities via endothelial protein C receptor and protease-activated receptor-1. APC mutants with selectively altered and opposite activity profiles, that is, greatly reduced anticoagulant activity or greatly reduced cytoprotective activities, are compared here. Glu149Ala-APC exhibited enhanced in vitro anticoagulant and in vivo antithrombotic activity, but greatly dimin
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- Mosnier, L O
- Zampolli, A
- Kerschen, E J
- Schuepbach, R A
- Banerjee, Y
- Fernández, J A
- Yang, X V
- Riewald, M
- Weiler, H
- Ruggeri, Z M
- Griffin, J H
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Mosnier, L. O., Zampolli, A., Kerschen, E. J., Schuepbach, R. A., Banerjee, Y., Fernández, J. A., Yang, X. V., Riewald, M., Weiler, H., Ruggeri, Z. M., & Griffin, J. H. (2009). Hyperantithrombotic, noncytoprotective Glu149Ala-activated protein C mutant. Blood, 113(23), 5970–5978. https://doi.org/10.1182/blood-2008-10-183327