Publication: Effect of tetra-hydroxylated bile acid on size and insulin sensitivity of subcutaneous adipocytes in healthy lean cats
Effect of tetra-hydroxylated bile acid on size and insulin sensitivity of subcutaneous adipocytes in healthy lean cats
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Rast, I. T., Zini, E., Wolfrum, C., Lutz, T. A., Reusch, C. E., & Salesov, E. (2022). Effect of tetra-hydroxylated bile acid on size and insulin sensitivity of subcutaneous adipocytes in healthy lean cats. Domestic Animal Endocrinology, 80, 106722. https://doi.org/10.1016/j.domaniend.2022.106722
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Obesity leads to insulin resistance and is a major risk factor for the development of diabetes mellitus in cats. Prevention of obesity and obesity-induced insulin resistance is difficult, and reliable long-term strategies are currently lacking. Retinoid-related orphan receptor gamma (RORγ) was recently identified as an important transcription factor in the development of large insulin-resistant adipocytes in mice and humans. RORγ negatively affects adipocyte differentiation through expression of its target gene matrix metalloproteinas
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- Rast, I T
- Zini, Eric
- Wolfrum, C
- Reusch, Claudia E
- Salesov, Elena
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Rast, I. T., Zini, E., Wolfrum, C., Lutz, T. A., Reusch, C. E., & Salesov, E. (2022). Effect of tetra-hydroxylated bile acid on size and insulin sensitivity of subcutaneous adipocytes in healthy lean cats. Domestic Animal Endocrinology, 80, 106722. https://doi.org/10.1016/j.domaniend.2022.106722
