Publication: Circulating levels of gastrointestinal hormones in prediabetes reversing to normoglycemia or progressing to diabetes in a year-A cross-sectional and prospective analysis
Circulating levels of gastrointestinal hormones in prediabetes reversing to normoglycemia or progressing to diabetes in a year-A cross-sectional and prospective analysis
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Hoffmann, C., Schwarz, P. E., Mantzoros, C. S., Birkenfeld, A. L., Wolfrum, C., Solimena, M., Bornstein, S. R., & Perakakis, N. (2023). Circulating levels of gastrointestinal hormones in prediabetes reversing to normoglycemia or progressing to diabetes in a year-A cross-sectional and prospective analysis. Diabetes Research and Clinical Practice, 199, 110636. https://doi.org/10.1016/j.diabres.2023.110636
Abstract
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AIMS
We aimed to compare the concentrations of GLP-1, glucagon and GIP (established regulators of glucose homeostasis) and glicentin (emerging new metabolic marker)during an OGTT in patients with normal glucose tolerance (NGT), prediabetes and diabetes at onset, and one-year before, when all had prediabetes.
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GLP-1, glucagon, GIP and glicentin concentrations were measured and compared with markers of body composition, insulin sensitivity and β-cell function at a 5-timepoint OGTT in 125 subjects (30 diabetes, 65 prediabetes,
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- Hoffmann, Carlotta
- Schwarz, Peter E
- Mantzoros, Christos S
- Birkenfeld, Andreas L
- Wolfrum, Christian
- Solimena, Michele
- Bornstein, Stefan R
- Perakakis, Nikolaos
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Hoffmann, C., Schwarz, P. E., Mantzoros, C. S., Birkenfeld, A. L., Wolfrum, C., Solimena, M., Bornstein, S. R., & Perakakis, N. (2023). Circulating levels of gastrointestinal hormones in prediabetes reversing to normoglycemia or progressing to diabetes in a year-A cross-sectional and prospective analysis. Diabetes Research and Clinical Practice, 199, 110636. https://doi.org/10.1016/j.diabres.2023.110636
