Publication: Therapeutic potential of interleukin-2 in autoimmune diseases
Therapeutic potential of interleukin-2 in autoimmune diseases
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Yuan, Y., Kolios, A. G. A., Liu, Y., Zhang, B., Li, H., Tsokos, G. C., & Zhang, X. (2022). Therapeutic potential of interleukin-2 in autoimmune diseases. Trends in Molecular Medicine, 28(7), 596–612. https://doi.org/10.1016/j.molmed.2022.04.010
Abstract
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Autoimmune diseases are characterized by dysregulation and aberrant activation of cells in the immune system. Therefore, restoration of the immune balance represents a promising therapeutic target in autoimmune diseases. Interleukin-2 (IL-2) can promote the expansion and differentiation of different immune cell subsets dose-dependently. At high doses, IL-2 can promote the differentiation and expansion of effector and memory T cells, whereas at low doses, IL-2 can promote the differentiation, survival, and function of regulatory T (Tre
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- Yuan, Yeshuang
- Kolios, Antonios G A
- Liu, Yudong
- Zhang, Bo
- Li, Hao
- Tsokos, George C
- Zhang, Xuan
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Yuan, Y., Kolios, A. G. A., Liu, Y., Zhang, B., Li, H., Tsokos, G. C., & Zhang, X. (2022). Therapeutic potential of interleukin-2 in autoimmune diseases. Trends in Molecular Medicine, 28(7), 596–612. https://doi.org/10.1016/j.molmed.2022.04.010
