Publication: Prediction of Drug-Induced Cholestasis Caused by Transporter and/or Enzyme Inhibition-Derived Cell Stress
Prediction of Drug-Induced Cholestasis Caused by Transporter and/or Enzyme Inhibition-Derived Cell Stress
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Kastrinou-Lampou, V. (2024). Prediction of Drug-Induced Cholestasis Caused by Transporter and/or Enzyme Inhibition-Derived Cell Stress. (Dissertation, University of Zurich) https://doi.org/10.5167/uzh-258652
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Drug-induced liver injury (DILI) is a life-threatening adverse reaction to drugs or xenobiotics with major concern for the pharmaceutical companies and health providers, as it represents a main cause of drug attrition and market drug withdrawal (1, 2). Drug-induced cholestasis (DIC) is characterized by disruption of bile flow, leading to accumulation of bile acids within the hepatocytes. Despite considered less severe compared to other hepatic adverse reactions, DIC is often chronic and can progress to liver cirrhosis and ultimately e
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Kastrinou-Lampou, V. (2024). Prediction of Drug-Induced Cholestasis Caused by Transporter and/or Enzyme Inhibition-Derived Cell Stress. (Dissertation, University of Zurich) https://doi.org/10.5167/uzh-258652
