Publication: Genetic association with response to intravitreal ranibizumab in patients with neovascular AMD
Genetic association with response to intravitreal ranibizumab in patients with neovascular AMD
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Kloeckener-Gruissem, B., Barthelmes, D., Labs, S., Schindler, C., Kurz-Levin, M., Michels, S., Fleischhauer, J., Berger, W., Sutter, F., & Menghini, M. (2011). Genetic association with response to intravitreal ranibizumab in patients with neovascular AMD. Investigative Ophthalmology and Visual Science, 52(7), 4694–4702. https://doi.org/10.1167/iovs.10-6080
Abstract
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Abstract
Purpose. Neovascular age-related macular degeneration (AMD) resulting in decreased central vision severely impairs affected individuals. Current standard treatment is an intravitreal anti-VEGF therapy (ranibizumab), but responses to treatment show large variability. Genetic factors that influence AMD and that affect the outcome of ranibizumab treatment were sought within a sample of Swiss patients. Methods. Changes in visual acuity (VA) after initiation of anti-VEGF treatment were observed during 12 months, and percentiles of VA were
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Creators (Authors)
- Kloeckener-Gruissem, B
- Barthelmes, D
- Labs, S
- Schindler, C
- Kurz-Levin, M
- Michels, S
- Fleischhauer, J
- Berger, W
- Sutter, F
- Menghini, M
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Kloeckener-Gruissem, B., Barthelmes, D., Labs, S., Schindler, C., Kurz-Levin, M., Michels, S., Fleischhauer, J., Berger, W., Sutter, F., & Menghini, M. (2011). Genetic association with response to intravitreal ranibizumab in patients with neovascular AMD. Investigative Ophthalmology and Visual Science, 52(7), 4694–4702. https://doi.org/10.1167/iovs.10-6080
