Publication: RSPO3 impairs barrier function of human vascular endothelial monolayers and synergizes with pro-inflammatory IL-1
RSPO3 impairs barrier function of human vascular endothelial monolayers and synergizes with pro-inflammatory IL-1
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Skaria, T., Bachli, E., & Schoedon, G. (2018). RSPO3 impairs barrier function of human vascular endothelial monolayers and synergizes with pro-inflammatory IL-1. Molecular Medicine, 24:45. https://doi.org/10.1186/s10020-018-0048-z
Abstract
Abstract
Abstract
BACKGROUND: Endothelial barrier dysfunction characterized by hyperpermeability of the vascular endothelium is a key factor in the pathogenesis of chronic inflammatory diseases and affects clinical outcomes. In states of chronic inflammation, mediators secreted by activated immune cells or vascular endothelium may affect the barrier function and permeability of the vascular endothelium. The matricellular R-spondin family member RSPO3 is produced by inflammatory-activated human monocytes and vascular endothelial cells, but its effects
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Creators (Authors)
- Skaria, Tom
- Bachli, Esther
- Schoedon, Gabriele
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Citations
Skaria, T., Bachli, E., & Schoedon, G. (2018). RSPO3 impairs barrier function of human vascular endothelial monolayers and synergizes with pro-inflammatory IL-1. Molecular Medicine, 24:45. https://doi.org/10.1186/s10020-018-0048-z
