Publication: Trimethylamine-N-oxide is associated with cardiovascular mortality and vascular brain lesions in patients with atrial fibrillation
Trimethylamine-N-oxide is associated with cardiovascular mortality and vascular brain lesions in patients with atrial fibrillation
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Luciani, M., Müller, D., Vanetta, C., Diteepeng, T., von Eckardstein, A., Aeschbacher, S., Rodondi, N., Moschovitis, G., Reichlin, T., Sinnecker, T., Wuerfel, J., Bonati, L. H., Saeedi Saravi, S. S., Chocano-Bedoya, P., Coslovsky, M., Camici, G. G., Lüscher, T. F., Kuehne, M., Osswald, S., … Beer, J. H. (2023). Trimethylamine-N-oxide is associated with cardiovascular mortality and vascular brain lesions in patients with atrial fibrillation. Heart, 109(5), 396–404. https://doi.org/10.1136/heartjnl-2022-321300
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OBJECTIVE
Trimethylamine-N-oxide (TMAO) is a metabolite derived from the microbial processing of dietary phosphatidylcholine and carnitine and the subsequent hepatic oxidation. Due to its prothrombotic and inflammatory mechanisms, we aimed to assess its role in the prediction of adverse events in a susceptible population, namely patients with atrial fibrillation.
METHODS
Baseline TMAO plasma levels were measured by liquid chromatography-tandem mass spectrometry in 2379 subjects from the ongoing Swiss Atrial Fibrillation cohort. 172
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Luciani, M., Müller, D., Vanetta, C., Diteepeng, T., von Eckardstein, A., Aeschbacher, S., Rodondi, N., Moschovitis, G., Reichlin, T., Sinnecker, T., Wuerfel, J., Bonati, L. H., Saeedi Saravi, S. S., Chocano-Bedoya, P., Coslovsky, M., Camici, G. G., Lüscher, T. F., Kuehne, M., Osswald, S., … Beer, J. H. (2023). Trimethylamine-N-oxide is associated with cardiovascular mortality and vascular brain lesions in patients with atrial fibrillation. Heart, 109(5), 396–404. https://doi.org/10.1136/heartjnl-2022-321300