Publication: Wnt/β-catenin signaling regulates sequential fate decisions of murine cortical precursor cells
Wnt/β-catenin signaling regulates sequential fate decisions of murine cortical precursor cells
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Draganova, K., Zemke, M., Zurkirchen, L., Valenta, T., Cantù, C., Okoniewski, M., Schmid, M.-T., Hoffmans, R., Götz, M., Basler, K., & Sommer, L. (2015). Wnt/β-catenin signaling regulates sequential fate decisions of murine cortical precursor cells. Stem Cells, 33(1), 170–182. https://doi.org/10.1002/stem.1820
Abstract
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Abstract
The fate of neural progenitor cells (NPC) is determined by a complex interplay of intrinsic programs and extrinsic signals, very few of which are known. β-catenin transduces extracellular Wnt signals, but also maintains adherens junctions integrity. Here, we identify for the first time the contribution of β-catenin transcriptional activity as opposed to its adhesion role in the development of the cerebral cortex by combining a novel β-catenin mutant allele with conditional inactivation approaches. Wnt/β-catenin signaling ablation lead
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- Draganova, Kalina
- Zemke, Martina
- Zurkirchen, Luis
- Valenta, Tomas
- Cantù, Claudio
- Okoniewski, Michal
- Schmid, Marie-Theres
- Hoffmans, Raymond
- Götz, Magdalena
- Sommer, Lukas
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Draganova, K., Zemke, M., Zurkirchen, L., Valenta, T., Cantù, C., Okoniewski, M., Schmid, M.-T., Hoffmans, R., Götz, M., Basler, K., & Sommer, L. (2015). Wnt/β-catenin signaling regulates sequential fate decisions of murine cortical precursor cells. Stem Cells, 33(1), 170–182. https://doi.org/10.1002/stem.1820