Publication: Prothrombotic response to norepinephrine infusion, mimicking norepinephrine stress-reactivity effects, is partly mediated by α-adrenergic mechanisms
Prothrombotic response to norepinephrine infusion, mimicking norepinephrine stress-reactivity effects, is partly mediated by α-adrenergic mechanisms
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von Känel, R., Heimgartner, N., Stutz, M., Zuccarella-Hackl, C., Hänsel, A., Ehlert, U., & Wirtz, P. H. (2019). Prothrombotic response to norepinephrine infusion, mimicking norepinephrine stress-reactivity effects, is partly mediated by α-adrenergic mechanisms. Psychoneuroendocrinology, 105, 44–50. https://doi.org/10.1016/j.psyneuen.2018.09.018
Abstract
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BACKGROUND: Stress-induced prothrombotic changes are mediated by the sympathetic nervous system and critically involved in mental triggering of acute coronary syndromes, but the underlying psychobiology is not fully understood. We tested the hypothesis that a norepinephrine (NE) infusion to mimic effects of stress-induced NE release on blood coagulation elicits prothrombotic changes and examined to what extent these would be mediated by an alpha-adrenergic mechanism. METHODS AND RESULTS: In a single-blind placebo-controlled within-sub
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Creators (Authors)
- Heimgartner, Nadja
- Stutz, Monika
- Zuccarella-Hackl, Claudia
- Hänsel, Alexander
- Ehlert, Ulrike
- Wirtz, Petra H
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SNSF
German Research Foundation
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PP00P1_128565
INST 38/550-1
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Psychoneurobiological mechanisms in essential hypertension and coronary heart disease
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von Känel, R., Heimgartner, N., Stutz, M., Zuccarella-Hackl, C., Hänsel, A., Ehlert, U., & Wirtz, P. H. (2019). Prothrombotic response to norepinephrine infusion, mimicking norepinephrine stress-reactivity effects, is partly mediated by α-adrenergic mechanisms. Psychoneuroendocrinology, 105, 44–50. https://doi.org/10.1016/j.psyneuen.2018.09.018