Publication: Regulation and function of SIRT1 in rheumatoid arthritis synovial fibroblasts
Regulation and function of SIRT1 in rheumatoid arthritis synovial fibroblasts
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Engler, A., Tange, C., Frank-Bertoncelj, M., Gay, R. E., Gay, S., & Ospelt, C. (2016). Regulation and function of SIRT1 in rheumatoid arthritis synovial fibroblasts. Journal of Molecular Medicine, 94(2), 173–182. https://doi.org/10.1007/s00109-015-1332-9
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Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation and destruction of synovial joints. The function of sirtuin (SIRT)1 in RA is inconclusive. In human synovial cells, SIRT1 was shown to promote cytokine production and apoptosis resistance. However, deletion of SIRT1 aggravated inflammatory arthritis in mice and increased production of pro-inflammatory cytokines in murine macrophages. In the current study, we investigated the regulation, expression, and function of SIRT1 in RA, in particular its rol
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- Engler, Anna
- Tange, Clare
- Frank-Bertoncelj, Mojca
- Gay, Renate E
- Gay, Steffen
- Ospelt, Caroline
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Engler, A., Tange, C., Frank-Bertoncelj, M., Gay, R. E., Gay, S., & Ospelt, C. (2016). Regulation and function of SIRT1 in rheumatoid arthritis synovial fibroblasts. Journal of Molecular Medicine, 94(2), 173–182. https://doi.org/10.1007/s00109-015-1332-9
