Publication: Effects of therapeutic plasma exchange on the endothelial glycocalyx in septic shock
Effects of therapeutic plasma exchange on the endothelial glycocalyx in septic shock
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Stahl, K., Hillebrand, U. C., Kiyan, Y., Seeliger, B., Schmidt, J. J., Schenk, H., Pape, T., Schmidt, B. M. W., Welte, T., Hoeper, M. M., Sauer, A., Wygrecka, M., Bode, C., Wedemeyer, H., Haller, H., & David, S. (2021). Effects of therapeutic plasma exchange on the endothelial glycocalyx in septic shock. Intensive Care Medicine Experimental, 9, 57. https://doi.org/10.1186/s40635-021-00417-4
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BACKGROUND: Disruption of the endothelial glycocalyx (eGC) is observed in septic patients and its injury is associated with multiple-organ failure and inferior outcomes. Besides this biomarker function, increased blood concentrations of shedded eGC constituents might play a mechanistic role in septic organ failure. We hypothesized that therapeutic plasma exchange (TPE) using fresh frozen plasma might influence eGC-related pathology by removing injurious mediators of eGC breakdown while at the time replacing eGC protective factors. MET
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Stahl, K., Hillebrand, U. C., Kiyan, Y., Seeliger, B., Schmidt, J. J., Schenk, H., Pape, T., Schmidt, B. M. W., Welte, T., Hoeper, M. M., Sauer, A., Wygrecka, M., Bode, C., Wedemeyer, H., Haller, H., & David, S. (2021). Effects of therapeutic plasma exchange on the endothelial glycocalyx in septic shock. Intensive Care Medicine Experimental, 9, 57. https://doi.org/10.1186/s40635-021-00417-4
