Publication: An interleukin-33-mast cell-interleukin-2 axis suppresses papain-induced allergic inflammation by promoting regulatory t cell numbers
An interleukin-33-mast cell-interleukin-2 axis suppresses papain-induced allergic inflammation by promoting regulatory t cell numbers
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Morita, H., Arae, K., Unno, H., Miyauchi, K., Toyama, S., Nambu, A., Oboki, K., Ohno, T., Motomura, K., Matsuda, A., Yamaguchi, S., Narushima, S., Kajiwara, N., Iikura, M., Suto, H., McKenzie, A. N. J., Takahashi, T., Karasuyama, H., Okumura, K., … Nakae, S. (2015). An interleukin-33-mast cell-interleukin-2 axis suppresses papain-induced allergic inflammation by promoting regulatory t cell numbers. Immunity, 43(1), 175–186. https://doi.org/10.1016/j.immuni.2015.06.021
Abstract
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Abstract
House dust mite-derived proteases contribute to allergic disorders in part by disrupting epithelial barrier function. Interleukin-33 (IL-33), produced by lung cells after exposure to protease allergens, can induce innate-type airway eosinophilia by activating natural helper (NH) cells, a member of group 2 innate lymphoid cells (ILC2), to secrete Th2 type-cytokines. Because IL-33 also can induce mast cells (MCs) to secrete Th2 type-cytokines, MCs are thought to cooperate with NH cells in enhancing protease or IL-33-mediated innate-type
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Creators (Authors)
- Morita, Hideaki
- Arae, Ken
- Unno, Hirotoshi
- Miyauchi, Kousuke
- Toyama, Sumika
- Nambu, Aya
- Oboki, Keisuke
- Ohno, Tatsukuni
- Motomura, Kenichiro
- Matsuda, Akira
- Yamaguchi, Sachiko
- Narushima, Seiko
- Kajiwara, Naoki
- Iikura, Motoyasu
- Suto, Hajime
- McKenzie, Andrew N J
- Takahashi, Takao
- Karasuyama, Hajime
- Okumura, Ko
- Azuma, Miyuki
- Moro, Kazuyo
- Akdis, Cezmi A
- Galli, Stephen J
- Koyasu, Shigeo
- Kubo, Masato
- Sudo, Katsuko
- Saito, Hirohisa
- Matsumoto, Kenji
- Nakae, Susumu
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Morita, H., Arae, K., Unno, H., Miyauchi, K., Toyama, S., Nambu, A., Oboki, K., Ohno, T., Motomura, K., Matsuda, A., Yamaguchi, S., Narushima, S., Kajiwara, N., Iikura, M., Suto, H., McKenzie, A. N. J., Takahashi, T., Karasuyama, H., Okumura, K., … Nakae, S. (2015). An interleukin-33-mast cell-interleukin-2 axis suppresses papain-induced allergic inflammation by promoting regulatory t cell numbers. Immunity, 43(1), 175–186. https://doi.org/10.1016/j.immuni.2015.06.021