Publication: CXCL11 is involved in leucocyte recruitment to the central nervous system in neuroborreliosis
CXCL11 is involved in leucocyte recruitment to the central nervous system in neuroborreliosis
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Rupprecht, T. A., Koedel, U., Muhlberger, B., Wilske, B., Fontana, A., & Pfister, H. W. (2005). CXCL11 is involved in leucocyte recruitment to the central nervous system in neuroborreliosis. Journal of Neurology, 252(7), 820–823. https://doi.org/10.1007/s00415-005-0752-9
Abstract
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We investigated the role of the CXCR3 chemokine CXCL11 (I-TAC) for leukocyte recruitment to the CSF in neuroborreliosis (NB). CXCL11 levels in the CSF of 17 patients with acute NB were elevated compared with 20 non-inflammatory controls (100.1 vs. 54.1 pg/ml, p = 0.002). Using a modified Boyden chamber chemotaxis-assay, the CSF of patients with acute NB was more chemotactic than the control CSF-samples (p = 0.001). A strong correlation (p < 0.001) between CXCL11 levels, chemotactic activity and CSF-white cell count was detected. Thoug
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- Rupprecht, T A
- Koedel, U
- Muhlberger, B
- Wilske, B
- Fontana, A
- Pfister, H W
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Rupprecht, T. A., Koedel, U., Muhlberger, B., Wilske, B., Fontana, A., & Pfister, H. W. (2005). CXCL11 is involved in leucocyte recruitment to the central nervous system in neuroborreliosis. Journal of Neurology, 252(7), 820–823. https://doi.org/10.1007/s00415-005-0752-9
