Publication: Treg-selective IL-2 starvation synergizes with CD40 activation to sustain durable responses in lymphoma models
Treg-selective IL-2 starvation synergizes with CD40 activation to sustain durable responses in lymphoma models
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Stirm, K., Leary, P., Wüst, D., Stark, D., Joller, N., Karakus, U., Boyman, O., Tzankov, A., & Müller, A. (2023). Treg-selective IL-2 starvation synergizes with CD40 activation to sustain durable responses in lymphoma models. Journal for ImmunoTherapy of Cancer, 11, e006263. https://doi.org/10.1136/jitc-2022-006263
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BACKGROUND: Roughly half of all diffuse large B-cell lymphomas (DLBCLs) are infiltrated by large numbers of regulatory T-cells (Tregs). Although the presence of 'effector' Tregs in particular is associated with an inferior prognosis in patients on standard rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) immunochemotherapy, the role of this cell type during lymphoma initiation and progression is poorly understood. METHODS: Here, we use tissue microarrays containing prospectively collected DLBCL patien
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- Stirm, Kristin
- Leary, Peter
- Wüst, Daria
- Stark, Dominique
- Karakus, Ufuk
- Boyman, Onur
- Tzankov, Alexandar
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Stirm, K., Leary, P., Wüst, D., Stark, D., Joller, N., Karakus, U., Boyman, O., Tzankov, A., & Müller, A. (2023). Treg-selective IL-2 starvation synergizes with CD40 activation to sustain durable responses in lymphoma models. Journal for ImmunoTherapy of Cancer, 11, e006263. https://doi.org/10.1136/jitc-2022-006263
