Publication: From Enigma to Revelation: Unravelling Biological Functions of Ubiquitous Small Ribozymes
From Enigma to Revelation: Unravelling Biological Functions of Ubiquitous Small Ribozymes
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Kienbeck, K., Malfertheiner, L., Zelger-Paulus, S., Johannsen, S., von Mering, C., & Sigel, R. K. O. (2024). From Enigma to Revelation: Unravelling Biological Functions of Ubiquitous Small Ribozymes. Chimia, 78, 200–204. https://doi.org/10.2533/chimia.2024.200
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Abstract
RNA, widely recognized as an information-carrier molecule, is capable of catalyzing essential biological processes through ribozymes. Despite their ubiquity, specific functions in a biological context and phenotypes based on the ribozymes' activity are often unknown. Here, we present the discovery of a subgroup of minimal HDV-like ribozymes, which reside 3' to viral tRNAs and appear to cleave the 3'-trailers of viral premature tRNA transcripts. This proposed tRNA-processing function is unprecedented for any ribozymes, thus, we designa
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- Kienbeck, Kasimir
- Malfertheiner, Lukas
- Zelger-Paulus, Susann
- Johannsen, Silke
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Kienbeck, K., Malfertheiner, L., Zelger-Paulus, S., Johannsen, S., von Mering, C., & Sigel, R. K. O. (2024). From Enigma to Revelation: Unravelling Biological Functions of Ubiquitous Small Ribozymes. Chimia, 78, 200–204. https://doi.org/10.2533/chimia.2024.200
