Publication: Legionella- and host-driven lipid flux at LCV-ER membrane contact sites promotes vacuole remodeling
Legionella- and host-driven lipid flux at LCV-ER membrane contact sites promotes vacuole remodeling
Date
Date
Date
Citations
Vormittag, S., Hüsler, D., Haneburger, I., Kroniger, T., Anand, A., Prantl, M., Barisch, C., Maaß, S., Becher, D., Letourneur, F., & Hilbi, H. (2023). Legionella- and host-driven lipid flux at LCV-ER membrane contact sites promotes vacuole remodeling. EMBO Reports, 24(3), e56007. https://doi.org/10.15252/embr.202256007
Abstract
Abstract
Abstract
Legionella pneumophila replicates in macrophages and amoeba within a unique compartment, the Legionella-containing vacuole (LCV). Hallmarks of LCV formation are the phosphoinositide lipid conversion from PtdIns(3)P to PtdIns(4)P, fusion with ER-derived vesicles and a tight association with the ER. Proteomics of purified LCVs indicate the presence of membrane contact sites (MCS) proteins possibly implicated in lipid exchange. Using dually fluorescence-labeled Dictyostelium discoideum amoeba, we reveal that VAMP-associated protein (Vap)
Additional indexing
Creators (Authors)
- Vormittag, Simone
- Hüsler, Dario
- Haneburger, Ina
- Kroniger, Tobias
- Anand, Aby
- Prantl, Manuel
- Barisch, Caroline
- Maaß, Sandra
- Becher, Dörte
- Letourneur, François
Volume
Volume
Volume
Number
Number
Number
Page range/Item number
Page range/Item number
Page range/Item number
Item Type
Item Type
Item Type
In collections
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Keywords
Language
Language
Language
Publication date
Publication date
Publication date
Date available
Date available
Date available
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
OA Status
OA Status
OA Status
Free Access at
Free Access at
Free Access at
Publisher DOI
Citations
Vormittag, S., Hüsler, D., Haneburger, I., Kroniger, T., Anand, A., Prantl, M., Barisch, C., Maaß, S., Becher, D., Letourneur, F., & Hilbi, H. (2023). Legionella- and host-driven lipid flux at LCV-ER membrane contact sites promotes vacuole remodeling. EMBO Reports, 24(3), e56007. https://doi.org/10.15252/embr.202256007
