Publication: Functionally important residues in the predicted 3(rd) transmembrane domain of the type IIa sodium-phosphate co-transporter (NaPi-IIa).
Functionally important residues in the predicted 3(rd) transmembrane domain of the type IIa sodium-phosphate co-transporter (NaPi-IIa).
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Forster, I. C., Bacconi, A., Biber, J., & Murer, H. (2005). Functionally important residues in the predicted 3(rd) transmembrane domain of the type IIa sodium-phosphate co-transporter (NaPi-IIa). Journal of Membrane Biology, 206, 227–238. https://doi.org/10.1007/s00232-005-0796-x
Abstract
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Abstract
The type IIa Na(+)/P(i), cotransporter (NaPi-IIa) mediates electrogenic transport of three Na(+) and one divalent P(i) ion (and one net positive charge) across the cell membrane. Sequence comparison of electrogenic NaPi-IIa and IIb isoforms with the electroneutral NaPi-IIc isoform pointed to the third transmembrane domain (TMD-3) as a possibly significant determinant of substrate binding. To elucidate the role of TMD-3 in the topology and mechanism underlying NaPi-IIa function we subjected it to cysteine scanning mutagenesis. The cons
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- Forster, I C
- Bacconi, A
- Biber, J
- Murer, H
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Forster, I. C., Bacconi, A., Biber, J., & Murer, H. (2005). Functionally important residues in the predicted 3(rd) transmembrane domain of the type IIa sodium-phosphate co-transporter (NaPi-IIa). Journal of Membrane Biology, 206, 227–238. https://doi.org/10.1007/s00232-005-0796-x
