Publication: A human antibody against pathologic IAPP aggregates protects beta cells in type 2 diabetes models
A human antibody against pathologic IAPP aggregates protects beta cells in type 2 diabetes models
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Wirth, F., Heitz, F. D., Seeger, C., Combaluzier, I., Breu, K., Denroche, H. C., Thevenet, J., Osto, M., Arosio, P., Kerr-Conte, J., Verchere, C. B., Pattou, F., Lutz, T. A., Donath, M. Y., Hock, C., Nitsch, R. M., & Grimm, J. (2023). A human antibody against pathologic IAPP aggregates protects beta cells in type 2 diabetes models. Nature Communications, 14(1), 6294. https://doi.org/10.1038/s41467-023-41986-0
Abstract
Abstract
Abstract
In patients with type 2 diabetes, pancreatic beta cells progressively degenerate and gradually lose their ability to produce insulin and regulate blood glucose. Beta cell dysfunction and loss is associated with an accumulation of aggregated forms of islet amyloid polypeptide (IAPP) consisting of soluble prefibrillar IAPP oligomers as well as insoluble IAPP fibrils in pancreatic islets. Here, we describe a human monoclonal antibody selectively targeting IAPP oligomers and neutralizing IAPP aggregate toxicity by preventing membrane disr
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Creators (Authors)
- Wirth, Fabian
- Heitz, Fabrice D
- Seeger, Christine
- Combaluzier, Ioana
- Breu, Karin
- Denroche, Heather C
- Thevenet, Julien
- Osto, Melania
- Arosio, Paolo
- Kerr-Conte, Julie
- Verchere, C Bruce
- Pattou, François
- Donath, Marc Y
- Hock, Christoph
- Nitsch, Roger M
- Grimm, Jan
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Wirth, F., Heitz, F. D., Seeger, C., Combaluzier, I., Breu, K., Denroche, H. C., Thevenet, J., Osto, M., Arosio, P., Kerr-Conte, J., Verchere, C. B., Pattou, F., Lutz, T. A., Donath, M. Y., Hock, C., Nitsch, R. M., & Grimm, J. (2023). A human antibody against pathologic IAPP aggregates protects beta cells in type 2 diabetes models. Nature Communications, 14(1), 6294. https://doi.org/10.1038/s41467-023-41986-0
