Publication: The skin commensal yeast malassezia triggers a type 17 response that coordinates anti-fungal immunity and exacerbates skin inflammation
The skin commensal yeast malassezia triggers a type 17 response that coordinates anti-fungal immunity and exacerbates skin inflammation
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Citations
Sparber, F., De Gregorio, C., Steckholzer, S., Ferreira, F. M., Dolowschiak, T., Ruchti, F., Kirchner, F. R., Mertens, S., Prinz, I., Joller, N., Buch, T., Glatz, M., Sallusto, F., & LeibundGut-Landmann, S. (2019). The skin commensal yeast malassezia triggers a type 17 response that coordinates anti-fungal immunity and exacerbates skin inflammation. Cell Host & Microbe, 25(3), 389-403.e6. https://doi.org/10.1016/j.chom.2019.02.002
Abstract
Abstract
Abstract
Commensal fungi of the mammalian skin, such as those of the genus Malassezia, are associated with atopic dermatitis and other common inflammatory skin disorders. Understanding of the causative relationship between fungal commensalism and disease manifestation remains incomplete. By developing a murine epicutaneous infection model, we found Malassezia spp. selectively induce IL-17 and related cytokines. This response is key in preventing fungal overgrowth on the skin, as disruption of the IL-23-IL-17 axis compromises Malassezia-specifi
Additional indexing
Creators (Authors)
- Sparber, Florian
- De Gregorio, Corinne
- Steckholzer, Simone
- Ferreira, Filipa M
- Dolowschiak, Tamas
- Ruchti, Fiorella
- Kirchner, Florian R
- Mertens, Sarah
- Prinz, Immo
- Glatz, Martin
- Sallusto, Federica
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Language
Language
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Date available
Date available
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Free Access at
Free Access at
Free Access at
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FP7
SNSF
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Grant ID
323183
PP00P3_150663
Project Title
Project Title
Project Title
PREDICT - Dissecting the human T cell response to pathogens, allergens, and self-antigens
Immune Regulation through Infection History
Citations
Sparber, F., De Gregorio, C., Steckholzer, S., Ferreira, F. M., Dolowschiak, T., Ruchti, F., Kirchner, F. R., Mertens, S., Prinz, I., Joller, N., Buch, T., Glatz, M., Sallusto, F., & LeibundGut-Landmann, S. (2019). The skin commensal yeast malassezia triggers a type 17 response that coordinates anti-fungal immunity and exacerbates skin inflammation. Cell Host & Microbe, 25(3), 389-403.e6. https://doi.org/10.1016/j.chom.2019.02.002
