Publication: Enhanced lysis by bispecific oncolytic measles viruses simultaneously using HER2/neu or EpCAM as target receptors
Enhanced lysis by bispecific oncolytic measles viruses simultaneously using HER2/neu or EpCAM as target receptors
Date
Date
Date
Citations
Hanauer, J. R., Gottschlich, L., Riehl, D., Rusch, T., Koch, V., Friedrich, K., Hutzler, S., Prüfer, S., Friedel, T., Hanschmann, K.-M., Münch, R. C., Jost, C., Plückthun, A., Cichutek, K., Buchholz, C. J., & Mühlebach, M. D. (2016). Enhanced lysis by bispecific oncolytic measles viruses simultaneously using HER2/neu or EpCAM as target receptors. Molecular Therapy : Oncolytics, 3, 16003. https://doi.org/10.1038/mto.2016.3
Abstract
Abstract
Abstract
To target oncolytic measles viruses (MV) to tumors, we exploit the binding specificity of designed ankyrin repeat proteins (DARPins). These DARPin-MVs have high tumor selectivity while maintaining excellent oncolytic potency. Stability, small size, and efficacy of DARPins allowed the generation of MVs simultaneously targeted to tumor marker HER2/neu and cancer stem cell (CSC) marker EpCAM. For optimization, the linker connecting both DARPins was varied in flexibility and length. Flexibility had no impact on fusion helper activity wher
Additional indexing
Creators (Authors)
- Gottschlich, Lisa
- Riehl, Dennis
- Rusch, Tillmann
- Koch, Vivian
- Friedrich, Katrin
- Hutzler, Stefan
- Prüfer, Steffen
- Friedel, Thorsten
- Hanschmann, Kay-Martin
- Münch, Robert C
- Jost, Christian
- Plückthun, Andreas
- Cichutek, Klaus
- Buchholz, Christian J
- Mühlebach, Michael D
Volume
Volume
Volume
Page range/Item number
Page range/Item number
Page range/Item number
Item Type
Item Type
Item Type
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Language
Language
Language
Publication date
Publication date
Publication date
Date available
Date available
Date available
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
OA Status
OA Status
OA Status
Free Access at
Free Access at
Free Access at
Publisher DOI
Citations
Hanauer, J. R., Gottschlich, L., Riehl, D., Rusch, T., Koch, V., Friedrich, K., Hutzler, S., Prüfer, S., Friedel, T., Hanschmann, K.-M., Münch, R. C., Jost, C., Plückthun, A., Cichutek, K., Buchholz, C. J., & Mühlebach, M. D. (2016). Enhanced lysis by bispecific oncolytic measles viruses simultaneously using HER2/neu or EpCAM as target receptors. Molecular Therapy : Oncolytics, 3, 16003. https://doi.org/10.1038/mto.2016.3
