Publication: MyD88-TLR4-dependent choroid plexus activation precedes perilesional inflammation and secondary brain edema in a mouse model of intracerebral hemorrhage
MyD88-TLR4-dependent choroid plexus activation precedes perilesional inflammation and secondary brain edema in a mouse model of intracerebral hemorrhage
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Akeret, K., Buzzi, R. M., Thomson, B. R., Schwendinger, N., Klohs, J., Schulthess-Lutz, N., Baselgia, L., Hansen, K., Regli, L., Vallelian, F., Hugelshofer, M., & Schaer, D. J. (2022). MyD88-TLR4-dependent choroid plexus activation precedes perilesional inflammation and secondary brain edema in a mouse model of intracerebral hemorrhage. Journal of Neuroinflammation, 19, 290. https://doi.org/10.1186/s12974-022-02641-5
Abstract
Abstract
Abstract
Background: The functional neurological outcome of patients with intracerebral hemorrhage (ICH) strongly relates to the degree of secondary brain injury (ICH-SBI) evolving within days after the initial bleeding. Different mechanisms including the incitement of inflammatory pathways, dysfunction of the blood–brain barrier (BBB), activation of resident microglia, and an influx of blood-borne immune cells, have been hypothesized to contribute to ICH-SBI. Yet, the spatiotemporal interplay of specific inflammatory processes within differen
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Creators (Authors)
- Akeret, Kevin
- Thomson, Bart R
- Schwendinger, Nina
- Klohs, Jan
- Schulthess-Lutz, Nadja
- Baselgia, Livio
- Hansen, Kerstin
- Regli, Luca
- Vallelian, Florence
- Hugelshofer, Michael
- Schaer, Dominik J
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Citations
Akeret, K., Buzzi, R. M., Thomson, B. R., Schwendinger, N., Klohs, J., Schulthess-Lutz, N., Baselgia, L., Hansen, K., Regli, L., Vallelian, F., Hugelshofer, M., & Schaer, D. J. (2022). MyD88-TLR4-dependent choroid plexus activation precedes perilesional inflammation and secondary brain edema in a mouse model of intracerebral hemorrhage. Journal of Neuroinflammation, 19, 290. https://doi.org/10.1186/s12974-022-02641-5
