Retinal regions shape human and murine Müller cell proteome profile and functionality

Kaplan, Lew; Drexler, Corinne; Pfaller, Anna M; Brenna, Santra; Wunderlich, Kirsten A; Dimitracopoulos, Andrea; Merl‐Pham, Juliane; Perez, Maria‐Theresa; Schlötzer‐Schrehardt, Ursula; Enzmann, Volker; Samardzija, Marijana; Puig, Berta; Fuchs, Peter; Franze, Kristian; Hauck, Stefanie M; Grosche, Antje

doi:10.1002/glia.24283

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Kaplan, L., Drexler, C., Pfaller, A. M., Brenna, S., Wunderlich, K. A., Dimitracopoulos, A., Merl‐Pham, J., Perez, M., Schlötzer‐Schrehardt, U., Enzmann, V., Samardzija, M., Puig, B., Fuchs, P., Franze, K., Hauck, S. M., & Grosche, A. (2023). Retinal regions shape human and murine Müller cell proteome profile and functionality. Glia, 71(2), 391–414. https://doi.org/10.1002/glia.24283

Abstract

The human macula is a highly specialized retinal region with pit‐like morphology and rich in cones. How Müller cells, the principal glial cell type in the retina, are adapted to this environment is still poorly understood. We compared proteomic data from cone‐ and rod‐rich retinae from human and mice and identified different expression profiles of cone‐ and rod‐associated Müller cells that converged on pathways representing extracellular matrix and cell adhesion. In particular, epiplakin (EPPK1), which is thought to play a role in int