Publication: Mcl-1 deficiency in murine livers leads to nuclear polyploidisation and mitotic errors: Implications for hepatocellular carcinoma
Mcl-1 deficiency in murine livers leads to nuclear polyploidisation and mitotic errors: Implications for hepatocellular carcinoma
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Clerbaux, L.-A., Cordier, P., Desboeufs, N., Unger, K., Leary, P., Semere, G., Boege, Y., Chan, L. K., Desdouets, C., Lopes, M., & Weber, A. (2023). Mcl-1 deficiency in murine livers leads to nuclear polyploidisation and mitotic errors: Implications for hepatocellular carcinoma. JHEP Reports, 5(10), 100838. https://doi.org/10.1016/j.jhepr.2023.100838
Abstract
Abstract
Abstract
BACKGROUND & AIMS
Mcl-1, an antiapoptotic protein overexpressed in many tumours, including hepatocellular carcinoma (HCC), represents a promising target for cancer treatment. Although Mcl-1 non-apoptotic roles might critically influence the therapeutic potential of Mcl-1 inhibitors, these functions remain poorly understood. We aimed to investigate the effects of hepatic Mcl-1 deficiency (Mcl-1$^{Δhep}$) on hepatocyte ploidy and cell cycle in murine liver in vivo and the possible implications on HCC.
METHODS
Livers of young Mcl-1$^{Δhep}$
Additional indexing
Creators (Authors)
- Clerbaux, Laure-Alix
- Cordier, Pierre
- Desboeufs, Nina
- Unger, Kristian
- Leary, Peter
- Semere, Gabriel
- Boege, Yannick
- Chan, Lap Kwan
- Desdouets, Chantal
- Lopes, Massimo
- Weber, Achim
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Citations
Clerbaux, L.-A., Cordier, P., Desboeufs, N., Unger, K., Leary, P., Semere, G., Boege, Y., Chan, L. K., Desdouets, C., Lopes, M., & Weber, A. (2023). Mcl-1 deficiency in murine livers leads to nuclear polyploidisation and mitotic errors: Implications for hepatocellular carcinoma. JHEP Reports, 5(10), 100838. https://doi.org/10.1016/j.jhepr.2023.100838
