Publication: Protein tyrosine phosphatase non-receptor type 22 modulates colitis in a microbiota-dependent manner
Protein tyrosine phosphatase non-receptor type 22 modulates colitis in a microbiota-dependent manner
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Spalinger, M. R., Schmidt, T. S. B., Schwarzfischer, M., Hering, L., Atrott, K., Lang, S., Gottier, C., Geirnaert, A., Lacroix, C., Dai, X., Rawlings, D. J., Chan, A. C., von Mering, C., Rogler, G., & Scharl, M. (2019). Protein tyrosine phosphatase non-receptor type 22 modulates colitis in a microbiota-dependent manner. Journal of Clinical Investigation, 129(6), 2527–2541. https://doi.org/10.1172/JCI123263
Abstract
Abstract
Abstract
The gut microbiota is crucial for our health, and well-balanced interactions between the host's immune system and the microbiota are essential to prevent chronic intestinal inflammation, as observed in inflammatory bowel diseases (IBD). A variant in protein tyrosine phosphatase non-receptor type 22 (PTPN22) is associated with reduced risk of developing IBD, but promotes the onset of autoimmune disorders. While the role of PTPN22 in modulating molecular pathways involved in IBD pathogenesis is well studied, its impact on shaping the in
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Creators (Authors)
- Spalinger, Marianne R
- Schmidt, Thomas S B
- Schwarzfischer, Marlene
- Hering, Larissa
- Atrott, Kirstin
- Lang, Silvia
- Gottier, Claudia
- Geirnaert, Annelies
- Lacroix, Christophe
- Dai, Xuezhi
- Rawlings, David J
- Chan, Andrew C
- von Mering, Christian
- Rogler, Gerhard
- Scharl, Michael
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Citations
Spalinger, M. R., Schmidt, T. S. B., Schwarzfischer, M., Hering, L., Atrott, K., Lang, S., Gottier, C., Geirnaert, A., Lacroix, C., Dai, X., Rawlings, D. J., Chan, A. C., von Mering, C., Rogler, G., & Scharl, M. (2019). Protein tyrosine phosphatase non-receptor type 22 modulates colitis in a microbiota-dependent manner. Journal of Clinical Investigation, 129(6), 2527–2541. https://doi.org/10.1172/JCI123263
