Publication: MRE11 complex links RECQ5 helicase to sites of DNA damage
MRE11 complex links RECQ5 helicase to sites of DNA damage
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Zheng, L., Kanagaraj, R., Mihaljevic, B., Schwendener, S., Sartori, A. A., Gerrits, B., Shevelev, I., & Janscak, P. (2009). MRE11 complex links RECQ5 helicase to sites of DNA damage. Nucleic Acids Research, 37, 2645–2657. https://doi.org/10.1093/nar/gkp147
Abstract
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Abstract
RECQ5 DNA helicase suppresses homologous recombination (HR) possibly through disruption of RAD51 filaments. Here, we show that RECQ5 is constitutively associated with the MRE11-RAD50-NBS1 (MRN) complex, a primary sensor of DNA double-strand breaks (DSBs) that promotes DSB repair and regulates DNA damage signaling via activation of the ATM kinase. Experiments with purified proteins indicated that RECQ5 interacts with the MRN complex through both MRE11 and NBS1. Functional assays revealed that RECQ5 specifically inhibited the 3'-->5' ex
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- Zheng, L
- Kanagaraj, R
- Mihaljevic, B
- Schwendener, S
- Gerrits, B
- Shevelev, I
- Janscak, Pavel
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Zheng, L., Kanagaraj, R., Mihaljevic, B., Schwendener, S., Sartori, A. A., Gerrits, B., Shevelev, I., & Janscak, P. (2009). MRE11 complex links RECQ5 helicase to sites of DNA damage. Nucleic Acids Research, 37, 2645–2657. https://doi.org/10.1093/nar/gkp147
