Publication: Intestinal inflammation alters mucosal carbohydrate foraging and monosaccharide incorporation into microbial glycans
Intestinal inflammation alters mucosal carbohydrate foraging and monosaccharide incorporation into microbial glycans
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Weiss, G. A., Grabinger, T., Glaus Garzon, J., Hasler, T., Greppi, A., Lacroix, C., Khanzhin, N., & Hennet, T. (2021). Intestinal inflammation alters mucosal carbohydrate foraging and monosaccharide incorporation into microbial glycans. Cellular Microbiology, 23(1), e13269. https://doi.org/10.1111/cmi.13269
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Endogenous carbohydrates released from the intestinal mucus represent a constant source of nutrients to the intestinal microbiota. Mucus-derived carbohydrates can also be used as building blocks in the biosynthesis of bacterial cell wall components, thereby influencing host mucosal immunity. To assess the uptake of endogenous carbohydrates by gut microbes in healthy mice and during intestinal inflammation, we applied azido-monosaccharides that can be tracked on bacterial cell walls after conjugation with fluorophores. In interleukin-1
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Weiss, G. A., Grabinger, T., Glaus Garzon, J., Hasler, T., Greppi, A., Lacroix, C., Khanzhin, N., & Hennet, T. (2021). Intestinal inflammation alters mucosal carbohydrate foraging and monosaccharide incorporation into microbial glycans. Cellular Microbiology, 23(1), e13269. https://doi.org/10.1111/cmi.13269