Publication: Targeting MDM2 enhances antileukemia immunity after allogeneic transplantation via MHC-II and TRAIL-R1/2 upregulation
Targeting MDM2 enhances antileukemia immunity after allogeneic transplantation via MHC-II and TRAIL-R1/2 upregulation
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Ho, J. N. H. G., Schmidt, D., Lowinus, T., Ryoo, J., Dopfer, E.-P., Gonzalo Núñez, N., Costa-Pereira, S., Toffalori, C., Punta, M., Fetsch, V., Wertheimer, T., Rittmann, M.-C., Braun, L. M., Follo, M., Briere, C., Vinnakota, J. M., Langenbach, M., Koppers, F., Shoumariyeh, K., … et al. (2022). Targeting MDM2 enhances antileukemia immunity after allogeneic transplantation via MHC-II and TRAIL-R1/2 upregulation. Blood, 140(10), 1167–1181. https://doi.org/10.1182/blood.2022016082
Abstract
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Abstract
Patients with acute myeloid leukemia (AML) often achieve remission after allogeneic hematopoietic cell transplantation (allo-HCT) but subsequently die of relapse driven by leukemia cells resistant to elimination by allogeneic T cells based on decreased major histocompatibility complex II (MHC-II) expression and apoptosis resistance. Here we demonstrate that mouse-double-minute-2 (MDM2) inhibition can counteract immune evasion of AML. MDM2 inhibition induced MHC class I and II expression in murine and human AML cells. Using xenografts
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Creators (Authors)
- Ho, Jenny N H G
- Schmidt, Dominik
- Lowinus, Theresa
- Ryoo, Jeongmin
- Dopfer, Elaine-Pashupati
- Gonzalo Núñez, Nicolás
- Costa-Pereira, Sara
- Toffalori, Cristina
- Punta, Marco
- Fetsch, Viktor
- Wertheimer, Tobias
- Rittmann, Marie-Claire
- Braun, Lukas M
- Follo, Marie
- Briere, Christelle
- Vinnakota, Janaki Manoja
- Langenbach, Marlene
- Koppers, Felicitas
- Shoumariyeh, Khalid
- Engel, Helena
- Rückert, Tamina
- Märklin, Melanie
- Holzmayer, Samuel
- Illert, Anna L
- Magon, Federica
- Andrieux, Geoffroy
- Duquesne, Sandra
- Pfeifer, Dietmar
- Staniek, Julian
- Rizzi, Marta
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Ho, J. N. H. G., Schmidt, D., Lowinus, T., Ryoo, J., Dopfer, E.-P., Gonzalo Núñez, N., Costa-Pereira, S., Toffalori, C., Punta, M., Fetsch, V., Wertheimer, T., Rittmann, M.-C., Braun, L. M., Follo, M., Briere, C., Vinnakota, J. M., Langenbach, M., Koppers, F., Shoumariyeh, K., … et al. (2022). Targeting MDM2 enhances antileukemia immunity after allogeneic transplantation via MHC-II and TRAIL-R1/2 upregulation. Blood, 140(10), 1167–1181. https://doi.org/10.1182/blood.2022016082