Publication: Optimizing Treatment Sequence for Late-line Metastatic Colorectal Cancer Patients Using Trifluridine/Tipiracil and Regorafenib
Optimizing Treatment Sequence for Late-line Metastatic Colorectal Cancer Patients Using Trifluridine/Tipiracil and Regorafenib
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Unseld, M., Drimmel, M., Siebenhüner, A., Gleiss, A., Bianconi, D., Kieler, M., Scheithauer, W., Winder, T., & Prager, G. W. (2018). Optimizing Treatment Sequence for Late-line Metastatic Colorectal Cancer Patients Using Trifluridine/Tipiracil and Regorafenib. Clinical Colorectal Cancer, 17(4), 274–279. https://doi.org/10.1016/j.clcc.2018.05.012
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BACKGROUND Treatment sequencing for patients with refractory metastatic colorectal cancer (mCRC) has been highly debated. The thymidine-based nucleoside trifluridine/tipiracil (TAS-102) and the multikinase inhibitor regorafenib have demonstrated clinical benefits in randomized phase III trials compared with placebo. However, limited data are available on the most optimal therapy sequence involving TAS-102 and regorafenib. PATIENTS AND METHODS In the present retrospective, observational, real-life study, clinical data on mCRC patient
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- Unseld, Matthias
- Drimmel, Magdalena
- Siebenhüner, Alexander
- Gleiss, Andreas
- Bianconi, Daniela
- Kieler, Markus
- Scheithauer, Werner
- Winder, Thomas
- Prager, Gerald W
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Unseld, M., Drimmel, M., Siebenhüner, A., Gleiss, A., Bianconi, D., Kieler, M., Scheithauer, W., Winder, T., & Prager, G. W. (2018). Optimizing Treatment Sequence for Late-line Metastatic Colorectal Cancer Patients Using Trifluridine/Tipiracil and Regorafenib. Clinical Colorectal Cancer, 17(4), 274–279. https://doi.org/10.1016/j.clcc.2018.05.012