Improvement of prognostic performance in severely injured patients by integrated clinico-transcriptomics: a translational approach

Rittirsch, Daniel; Schoenborn, Veit; Lindig, Sandro; Wanner, Elisabeth; Sprengel, Kai; Günkel, Sebastian; Schaarschmidt, Barbara; Märsmann, Sonja; Simmen, Hans-Peter; Cinelli, Paolo; Bauer, Michael; Claus, Ralf A; Wanner, Guido A

doi:10.1186/s13054-015-1127-y

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Rittirsch, D., Schoenborn, V., Lindig, S., Wanner, E., Sprengel, K., Günkel, S., Schaarschmidt, B., Märsmann, S., Simmen, H.-P., Cinelli, P., Bauer, M., Claus, R. A., & Wanner, G. A. (2015). Improvement of prognostic performance in severely injured patients by integrated clinico-transcriptomics: a translational approach. Critical Care, 19, 414. https://doi.org/10.1186/s13054-015-1127-y

Abstract

INTRODUCTION Severe trauma triggers a systemic inflammatory response that contributes to secondary complications, such as nosocomial infections, sepsis or multi-organ failure. The present study was aimed to identify markers predicting complications and an adverse outcome of severely injured patients by an integrated clinico-transcriptomic approach. METHODS In a prospective study, RNA samples from circulating leukocytes from severely injured patients (injury severity score ≥ 17 points; n = 104) admitted to a Level I Trauma Center we