Impact of 1-hour and 3-hour sepsis time bundles on patient outcomes and antimicrobial use: A before and after cohort study

Venkatesh, Balasubramanian; Schlapbach, Luregn; Mason, Donna; Wilks, Kathryn; Seaton, Robert; Lister, Paula; Irwin, Adam; Lane, Paul; Redpath, Lyndell; Gibbons, Kristen; Ergetu, Endrias; Rice, Michael

doi:10.1016/j.lanwpc.2021.100305

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Venkatesh, B., Schlapbach, L., Mason, D., Wilks, K., Seaton, R., Lister, P., Irwin, A., Lane, P., Redpath, L., Gibbons, K., Ergetu, E., & Rice, M. (2022). Impact of 1-hour and 3-hour sepsis time bundles on patient outcomes and antimicrobial use: A before and after cohort study. The Lancet Regional Health. Western Pacific, 18, 100305. https://doi.org/10.1016/j.lanwpc.2021.100305

Abstract

Background Sepsis bundles, promulgated by Surviving Sepsis Campaign have not been widely adopted because of variability in sepsis identification strategies, implementation challenges, concerns about excess antimicrobial use, and limited evidence of benefit. Methods A 1-hour septic shock and a 3-hour sepsis bundle were implemented using a Breakthrough Series Collaborative in 14 public hospitals in Queensland, Australia. A before (baseline) and after (post-intervention) study evaluated its impact on outcomes and antimicrobial prescripti