Paediatric aortic valve replacement using decellularized allografts: a multicentre update following 143 implantations and five-year mean follow-up

Horke, Alexander; Bobylev, Dmitry; Avsar, Murat; Cvitkovic, Tomislav; Meyns, Bart; Rega, Filip; Hazekamp, Mark; Cesnjevar, Robert; Schmiady, Martin; Staebler, Brigitte; Dewald, Oliver; Ciubotaru, Anatol; Michel-Behnke, Ina; Zimpfer, Daniel; Jashari, Ramadan; Boethig, Dietmar; Cebotari, Serghei; Beerbaum, Philipp; Tudorache, Igor; Sarikouch, Samir

doi:10.1093/ejcts/ezae112

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Horke, A., Bobylev, D., Avsar, M., Cvitkovic, T., Meyns, B., Rega, F., Hazekamp, M., Cesnjevar, R., Schmiady, M., Staebler, B., Dewald, O., Ciubotaru, A., Michel-Behnke, I., Zimpfer, D., Jashari, R., Boethig, D., Cebotari, S., Beerbaum, P., Tudorache, I., & Sarikouch, S. (2024). Paediatric aortic valve replacement using decellularized allografts: a multicentre update following 143 implantations and five-year mean follow-up. European Journal of Cardio-Thoracic Surgery, 65(4), ezae112. https://doi.org/10.1093/ejcts/ezae112

Abstract

OBJECTIVES: Decellularized aortic homografts (DAH) were introduced in 2008 as a further option for paediatric aortic valve replacement (AVR).

METHODS: Prospective, multicentre follow-up of all paediatric patients receiving DAH for AVR in 8 European centres.

RESULTS: A total of 143 DAH were implanted between February 2008 and February 2023 in 137 children (106 male, 74%) with a median age of 10.8 years (interquartile range 6.6-14.6). Eighty-four (59%) had undergone previous cardiac operations and 24 (17%) had undergone previous AVR.