Transfer of anti-rotavirus antibodies during pregnancy and in milk following maternal vaccination with a herpes simplex virus type-1 amplicon vector

Meier, Anita; Suter, Mark; Schraner, Elisabeth; Humbel, Bruno; Tobler, Kurt; Ackermann, Mathias; Laimbacher, Andrea

doi:10.5167/uzh-135691

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Meier, A., Suter, M., Schraner, E., Humbel, B., Tobler, K., Ackermann, M., & Laimbacher, A. (2017). Transfer of anti-rotavirus antibodies during pregnancy and in milk following maternal vaccination with a herpes simplex virus type-1 amplicon vector. International Journal of Molecular Sciences, 18, E431. https://doi.org/10.3390/ijms18020431

Abstract

Rotaviruses (RVs) are important enteric pathogens of newborn humans and animals, causing diarrhea and in rare cases death, especially in very young individuals. Rotavirus vaccines presently used are modified live vaccines that lack complete biological safety. Previous work from our laboratory suggested that vaccines based on in situ produced, non-infectious rotavirus-like particles (RVLPs) are efficient while being entirely safe. However, using either vaccine, active mucosal immunization cannot induce protective immunity in newborns d