Neural correlates of polygenic risk score for autism spectrum disorders in general population

Khundrakpam, Budhachandra; Vainik, Uku; Gong, Jinnan; Al-Sharif, Noor; Bhutani, Neha; Kiar, Gregory; Zeighami, Yashar; Kirschner, Matthias; Luo, Cheng; Dagher, Alain; Evans, Alan

doi:10.1093/braincomms/fcaa092

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Khundrakpam, B., Vainik, U., Gong, J., Al-Sharif, N., Bhutani, N., Kiar, G., Zeighami, Y., Kirschner, M., Luo, C., Dagher, A., & Evans, A. (2020). Neural correlates of polygenic risk score for autism spectrum disorders in general population. Brain Communications, 2(2), fcaa092. https://doi.org/10.1093/braincomms/fcaa092

Abstract

Autism spectrum disorder is a highly prevalent and highly heritable neurodevelopmental condition, but studies have mostly taken traditional categorical diagnosis approach (yes/no for autism spectrum disorder). In contrast, an emerging notion suggests a continuum model of autism spectrum disorder with a normal distribution of autistic tendencies in the general population, where a full diagnosis is at the severe tail of the distribution. We set out to investigate such a viewpoint by investigating the interaction of polygenic risk scores