Publication: A genome‐wide association meta‐analysis of all‐cause and vascular dementia
A genome‐wide association meta‐analysis of all‐cause and vascular dementia
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MEGAVCID consortium, Grünblatt, E., & et al. (2024). A genome‐wide association meta‐analysis of all‐cause and vascular dementia. Alzheimer’s & Dementia, 20(9), 5973–5995. https://doi.org/10.1002/alz.14115
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Introduction: Dementia is a multifactorial disease with Alzheimer's disease (AD) and vascular dementia (VaD) pathologies making the largest contributions. Yet, most genome-wide association studies (GWAS) focus on AD.
Methods: We conducted a GWAS of all-cause dementia (ACD) and examined the genetic overlap with VaD. Our dataset includes 800,597 individuals, with 46,902 and 8702 cases of ACD and VaD, respectively. Known AD loci for ACD and VaD were replicated. Bioinformatic analyses prioritized genes that are likely functionally releva
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MEGAVCID consortium, Grünblatt, E., & et al. (2024). A genome‐wide association meta‐analysis of all‐cause and vascular dementia. Alzheimer’s & Dementia, 20(9), 5973–5995. https://doi.org/10.1002/alz.14115
