Excitatory-inhibitory balance within EEG microstates and resting-state fMRI networks: assessed via simultaneous trimodal PET-MR-EEG imaging

Rajkumar, Ravichandran; Régio Brambilla, Cláudia; Veselinović, Tanja; Bierbrier, Joshua; Wyss, Christine; Ramkiran, Shukti; Orth, Linda; Lang, Markus; Rota Kops, Elena; Mauler, Jörg; Scheins, Jürgen; Neumaier, Bernd; Ermert, Johannes; Herzog, Hans; Langen, Karl-Josef; Binkofski, Ferdinand Christoph; Lerche, Christoph; Shah, N Jon; Neuner, Irene

doi:10.1038/s41398-020-01160-2

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Rajkumar, R., Régio Brambilla, C., Veselinović, T., Bierbrier, J., Wyss, C., Ramkiran, S., Orth, L., Lang, M., Rota Kops, E., Mauler, J., Scheins, J., Neumaier, B., Ermert, J., Herzog, H., Langen, K.-J., Binkofski, F. C., Lerche, C., Shah, N. J., & Neuner, I. (2021). Excitatory-inhibitory balance within EEG microstates and resting-state fMRI networks: assessed via simultaneous trimodal PET-MR-EEG imaging. Translational Psychiatry, 11, 60. https://doi.org/10.1038/s41398-020-01160-2

Abstract

The symbiosis of neuronal activities and glucose energy metabolism is reflected in the generation of functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) signals. However, their association with the balance between neuronal excitation and inhibition (E/I-B), which is closely related to the activities of glutamate and γ-aminobutyric acid (GABA) and the receptor availability (RA) of GABAA and mGluR5, remains unexplored. This research investigates these associations during the resting state (RS) condition using s