Publication: Chromatin Conformation Capture-Based Analysis of Nuclear Architecture
Chromatin Conformation Capture-Based Analysis of Nuclear Architecture
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Grob, S., & Grossniklaus, U. (2017). Chromatin Conformation Capture-Based Analysis of Nuclear Architecture. In I. Kovalchuk (Ed.), Plant Epigenetics (No. 1456; Vol. 1456, Issue 1456, pp. 15–32). Springer. https://doi.org/10.1007/978-1-4899-7708-3_2
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Nuclear organization and higher-order chromosome structure in interphase nuclei are thought to have important effects on fundamental biological processes, including chromosome condensation, replication, and transcription. Until recently, however, nuclear organization could only be analyzed microscopically. The development of chromatin conformation capture (3C)-based techniques now allows a detailed look at chromosomal architecture from the level of individual loci to the entire genome. Here we provide a robust Hi-C protocol, allowing
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Grob, S., & Grossniklaus, U. (2017). Chromatin Conformation Capture-Based Analysis of Nuclear Architecture. In I. Kovalchuk (Ed.), Plant Epigenetics (No. 1456; Vol. 1456, Issue 1456, pp. 15–32). Springer. https://doi.org/10.1007/978-1-4899-7708-3_2