Publication: Efficient pre-mRNA cleavage prevents replication-stress-associated genome instability
Efficient pre-mRNA cleavage prevents replication-stress-associated genome instability
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Teloni, F., Michelena, J., Lezaja, A., Kilic, S., Ambrosi, C., Menon, S., Dobrovolna, J., Imhof, R., Janscak, P., Baubec, T., & Altmeyer, M. (2019). Efficient pre-mRNA cleavage prevents replication-stress-associated genome instability. Molecular Cell, 73(4), 670-683.e12. https://doi.org/10.1016/j.molcel.2018.11.036
Abstract
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Abstract
Cellular mechanisms that safeguard genome integrity are often subverted in cancer. To identify cancer-related genome caretakers, we employed a convergent multi-screening strategy coupled to quantitative image-based cytometry and ranked candidate genes according to multivariate readouts reflecting viability, proliferative capacity, replisome integrity, and DNA damage signaling. This unveiled regulators of replication stress resilience, including components of the pre-mRNA cleavage and polyadenylation complex. We show that deregulation
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- Teloni, Federico
- Michelena, Jone
- Lezaja, Aleksandra
- Kilic, Sinan
- Ambrosi, Christina
- Menon, Shruti
- Dobrovolna, Jana
- Imhof, Ralph
- Janscak, Pavel
- Altmeyer, Matthias
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Teloni, F., Michelena, J., Lezaja, A., Kilic, S., Ambrosi, C., Menon, S., Dobrovolna, J., Imhof, R., Janscak, P., Baubec, T., & Altmeyer, M. (2019). Efficient pre-mRNA cleavage prevents replication-stress-associated genome instability. Molecular Cell, 73(4), 670-683.e12. https://doi.org/10.1016/j.molcel.2018.11.036
