Publication: Glutamatergic and GABAergic gene sets in attention-deficit/hyperactivity disorder: association to overlapping traits in ADHD and autism
Glutamatergic and GABAergic gene sets in attention-deficit/hyperactivity disorder: association to overlapping traits in ADHD and autism
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Naaijen, J., Bralten, J., Poelmans, G., IMAGE consortium, Glennon, J. C., Franke, B., & Buitelaar, J. K. (2017). Glutamatergic and GABAergic gene sets in attention-deficit/hyperactivity disorder: association to overlapping traits in ADHD and autism. Translational Psychiatry, 7(1), e999. https://doi.org/10.1038/tp.2016.273
Abstract
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Abstract
Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorders (ASD) often co-occur. Both are highly heritable; however, it has been difficult to discover genetic risk variants. Glutamate and GABA are main excitatory and inhibitory neurotransmitters in the brain; their balance is essential for proper brain development and functioning. In this study we investigated the role of glutamate and GABA genetics in ADHD severity, autism symptom severity and inhibitory performance, based on gene set analysis, an approach to inves
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- Naaijen, J
- Bralten, J
- Poelmans, G
- Glennon, J C
- Franke, B
- Buitelaar, J K
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Citations
Naaijen, J., Bralten, J., Poelmans, G., IMAGE consortium, Glennon, J. C., Franke, B., & Buitelaar, J. K. (2017). Glutamatergic and GABAergic gene sets in attention-deficit/hyperactivity disorder: association to overlapping traits in ADHD and autism. Translational Psychiatry, 7(1), e999. https://doi.org/10.1038/tp.2016.273
