Publication: Narcolepsy - clinical spectrum, aetiopathophysiology, diagnosis and treatment
Narcolepsy - clinical spectrum, aetiopathophysiology, diagnosis and treatment
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Bassetti, C. L. A., Adamantidis, A., Burdakov, D., Han, F., Gay, S., Kallweit, U., Khatami, R., Koning, F., Kornum, B. R., Lammers, G. J., Liblau, R. S., Luppi, P. H., Mayer, G., Pollmächer, T., Sakurai, T., Sallusto, F., Scammell, T. E., Tafti, M., & Dauvilliers, Y. (2019). Narcolepsy - clinical spectrum, aetiopathophysiology, diagnosis and treatment. Nature Reviews. Neurology, 15, 519–539. https://doi.org/10.1038/s41582-019-0226-9
Abstract
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Abstract
Narcolepsy is a rare brain disorder that reflects a selective loss or dysfunction of orexin (also known as hypocretin) neurons of the lateral hypothalamus. Narcolepsy type 1 (NT1) is characterized by excessive daytime sleepiness and cataplexy, accompanied by sleep-wake symptoms, such as hallucinations, sleep paralysis and disturbed sleep. Diagnosis is based on these clinical features and supported by biomarkers: evidence of rapid eye movement sleep periods soon after sleep onset; cerebrospinal fluid orexin deficiency; and positivity f
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Creators (Authors)
- Bassetti, Claudio L A
- Adamantidis, Antoine
- Burdakov, Denis
- Han, Fang
- Gay, Steffen
- Kallweit, Ulf
- Khatami, Ramin
- Koning, Frits
- Kornum, Brigitte R
- Lammers, Gert Jan
- Liblau, Roland S
- Luppi, Pierre H
- Mayer, Geert
- Pollmächer, Thomas
- Sakurai, Takeshi
- Sallusto, Federica
- Scammell, Thomas E
- Tafti, Mehdi
- Dauvilliers, Yves
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Citations
Bassetti, C. L. A., Adamantidis, A., Burdakov, D., Han, F., Gay, S., Kallweit, U., Khatami, R., Koning, F., Kornum, B. R., Lammers, G. J., Liblau, R. S., Luppi, P. H., Mayer, G., Pollmächer, T., Sakurai, T., Sallusto, F., Scammell, T. E., Tafti, M., & Dauvilliers, Y. (2019). Narcolepsy - clinical spectrum, aetiopathophysiology, diagnosis and treatment. Nature Reviews. Neurology, 15, 519–539. https://doi.org/10.1038/s41582-019-0226-9
