Publication: Protective effects of farnesoid X receptor (FXR) on hepatic lipid accumulation are mediated by hepatic FXR and independent of intestinal FGF15 signal
Protective effects of farnesoid X receptor (FXR) on hepatic lipid accumulation are mediated by hepatic FXR and independent of intestinal FGF15 signal
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Schmitt, J., Kong, B., Stieger, B., Tschopp, O., Schultze, S. M., Rau, M., Weber, A., Muellhaupt, B., Guo, G. L., & Geier, A. (2015). Protective effects of farnesoid X receptor (FXR) on hepatic lipid accumulation are mediated by hepatic FXR and independent of intestinal FGF15 signal. Liver International, 35(4), 1133–1144. https://doi.org/10.1111/liv.12456
Abstract
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Background & Aims There is a growing evidence that bile acids are involved in the regulation of triglyceride-, cholesterol-homoeostasis and fat absorption. In this study organ-specific Fxr knockout mice were used to further investigate the influence of farnesoid X receptor FXR in lipogenesis. Methods Liver- and intestine-specific Fxr knockout mice were fed a 1% cholesterol diet for 28 days. Histological examination of frozen tissue sections included Sudan III/H&E, BODIPY staining and liver X receptor (LXR) immunohistochemistry. Liver
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- Schmitt, Johannes
- Kong, Bo
- Stieger, Bruno
- Tschopp, Oliver
- Schultze, Simon M
- Rau, Monika
- Weber, Achim
- Muellhaupt, Beat
- Guo, Grace L
- Geier, Andreas
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Schmitt, J., Kong, B., Stieger, B., Tschopp, O., Schultze, S. M., Rau, M., Weber, A., Muellhaupt, B., Guo, G. L., & Geier, A. (2015). Protective effects of farnesoid X receptor (FXR) on hepatic lipid accumulation are mediated by hepatic FXR and independent of intestinal FGF15 signal. Liver International, 35(4), 1133–1144. https://doi.org/10.1111/liv.12456
