Publication: DNA quality control by conformational readout on the undamaged strand of the double helix.
DNA quality control by conformational readout on the undamaged strand of the double helix.
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Buterin, T., Meyer, C., Giese, B., & Naegeli, H. (2005). DNA quality control by conformational readout on the undamaged strand of the double helix. Chemistry & Biology, 12(8), 913–922. https://doi.org/10.1016/j.chembiol.2005.06.011
Abstract
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Synthetic DNA probes were incubated in human cell extracts to dissect the early step of bulky lesion recognition in the nucleotide excision repair pathway. Excision was induced upon combination of the target adduct with either a two-sided bulge, involving both the damaged sequence and its undamaged partner strand, or a one-sided bulge, affecting exclusively the undamaged complementary sequence. Surprisingly, the same adduct became refractory to repair when only the modified strand was bulged out of the double helix. Adduct removal was
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- Buterin, T
- Meyer, C
- Giese, B
- Naegeli, H
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Citations
Buterin, T., Meyer, C., Giese, B., & Naegeli, H. (2005). DNA quality control by conformational readout on the undamaged strand of the double helix. Chemistry & Biology, 12(8), 913–922. https://doi.org/10.1016/j.chembiol.2005.06.011
