Publication: Canonical wnt signaling is required for commissural axon guidance
Canonical wnt signaling is required for commissural axon guidance
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Avilés, E. C., & Stoeckli, E. T. (2016). Canonical wnt signaling is required for commissural axon guidance. Developmental Neurobiology, 76, 190–208. https://doi.org/10.1002/dneu.22307
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Morphogens have been identified as guidance cues for postcrossing commissural axons in the spinal cord. Shh has a dual effect on postcrossing commissural axons: a direct repellent effect mediated by Hhip as a receptor, and an indirect effect by shaping a Wnt activity gradient. Wnts were shown to be attractants for postcrossing commissural axons in both chicken and mouse embryos. In mouse, the effects of Wnts on axon guidance were concluded to depend on the planar cell polarity (PCP) pathway. Canonical Wnt signaling was excluded based
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- Avilés, Evelyn C
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Avilés, E. C., & Stoeckli, E. T. (2016). Canonical wnt signaling is required for commissural axon guidance. Developmental Neurobiology, 76, 190–208. https://doi.org/10.1002/dneu.22307
