Publication: Cardiac remodelling hinders activation of cyclooxygenase-2, diminishing protection by delayed pharmacological preconditioning: role of HIF1 alpha and CREB
Cardiac remodelling hinders activation of cyclooxygenase-2, diminishing protection by delayed pharmacological preconditioning: role of HIF1 alpha and CREB
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Feng, J., Lucchinetti, E., Fischer, G., Zhu, M., Zaugg, K., Schaub, M. C., & Zaugg, M. (2008). Cardiac remodelling hinders activation of cyclooxygenase-2, diminishing protection by delayed pharmacological preconditioning: role of HIF1 alpha and CREB. Cardiovascular Research, 78, 98–107. https://doi.org/10.1093/cvr/cvn016
Abstract
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AIMS: We tested whether delayed pharmacologic preconditioning elicited by isoflurane is protective in infarct-remodelled hearts. METHODS AND RESULTS: Male Wistar rats were treated with the preconditioning drug isoflurane 6 weeks after permanent ligation of the left anterior descending coronary artery. Twenty-four and 48 h later, hearts were perfused on the Langendorff system and treated with cyclooxygenase-2 or 12-lipoxygenase inhibitors before exposure to 40 min of ischaemia followed by 90 min of reperfusion. Infarct size was determi
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- Feng, Jianhua
- Lucchinetti, Eliana
- Fischer, Gregor
- Zhu, Min
- Zaugg, Kathrin
- Schaub, Marcus C
- Zaugg, Michael
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Publications of Institute of Anesthesiology
Publications of Institute of Laboratory Animal Science
Publications of Institute of Laboratory Animal Science
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Publications of Zurich Center for Integrative Human Physiology (ZIHP)
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Feng, J., Lucchinetti, E., Fischer, G., Zhu, M., Zaugg, K., Schaub, M. C., & Zaugg, M. (2008). Cardiac remodelling hinders activation of cyclooxygenase-2, diminishing protection by delayed pharmacological preconditioning: role of HIF1 alpha and CREB. Cardiovascular Research, 78, 98–107. https://doi.org/10.1093/cvr/cvn016
