Publication: Signal Propagation Within the MCL-1/BIM Protein Complex
Signal Propagation Within the MCL-1/BIM Protein Complex
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Heckmeier, P. J., Ruf, J., Buhrke, D., Janković, B. G., & Hamm, P. (2022). Signal Propagation Within the MCL-1/BIM Protein Complex. Journal of Molecular Biology, 434(17), 167499. https://doi.org/10.1016/j.jmb.2022.167499
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The protein MCL-1 is a crucial factor in regulating apoptosis, the programmed cell death, and thus plays a major role in numerous cancer types. The allosteric protein MCL-1 is naturally moderated by the BH3-only peptide BIM, which binds at its canonical binding groove. In its isolated form, BIM is disordered but assumes an -helical shape when bound by MCL-1. The underlying binding mechanism (i.e., induced fit vs conformational selection), as well as the time scales of the signal cascade subsequent to binding, are not understood. Here,
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- Heckmeier, Philipp J
- Ruf, Jeannette
- Buhrke, David
- Janković, Brankica G
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Heckmeier, P. J., Ruf, J., Buhrke, D., Janković, B. G., & Hamm, P. (2022). Signal Propagation Within the MCL-1/BIM Protein Complex. Journal of Molecular Biology, 434(17), 167499. https://doi.org/10.1016/j.jmb.2022.167499
