Publication: The β-catenin C terminus links Wnt and sphingosine-1-phosphate signaling pathways to promote vascular remodeling and atherosclerosis
The β-catenin C terminus links Wnt and sphingosine-1-phosphate signaling pathways to promote vascular remodeling and atherosclerosis
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Oliveira-Paula, G. H., Liu, S., Maira, A., Ressa, G., Ferreira, G. C., Quintar, A., Jayakumar, S., Almonte, V., Parikh, D., Valenta, T., Basler, K., Hla, T., Riascos-Bernal, D. F., & Sibinga, N. E. S. (2024). The β-catenin C terminus links Wnt and sphingosine-1-phosphate signaling pathways to promote vascular remodeling and atherosclerosis. Science Advances, 10, eadg9278. https://doi.org/10.1126/sciadv.adg9278
Abstract
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Abstract
Canonical Wnt and sphingosine-1-phosphate (S1P) signaling pathways are highly conserved systems that contribute to normal vertebrate development, with key consequences for immune, nervous, and cardiovascular system function; despite these functional overlaps, little is known about Wnt/β-catenin-S1P cross-talk. In the vascular system, both Wnt/β-catenin and S1P signals affect vessel maturation, stability, and barrier function, but information regarding their potential coordination is scant. We report an instance of functional interacti
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- Oliveira-Paula, Gustavo H
- Liu, Sophia
- Maira, Alishba
- Ressa, Gaia
- Ferreira, Graziele C
- Quintar, Amado
- Jayakumar, Smitha
- Almonte, Vanessa
- Parikh, Dippal
- Valenta, Tomas
- Hla, Timothy
- Riascos-Bernal, Dario F
- Sibinga, Nicholas E S
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Oliveira-Paula, G. H., Liu, S., Maira, A., Ressa, G., Ferreira, G. C., Quintar, A., Jayakumar, S., Almonte, V., Parikh, D., Valenta, T., Basler, K., Hla, T., Riascos-Bernal, D. F., & Sibinga, N. E. S. (2024). The β-catenin C terminus links Wnt and sphingosine-1-phosphate signaling pathways to promote vascular remodeling and atherosclerosis. Science Advances, 10, eadg9278. https://doi.org/10.1126/sciadv.adg9278
