Publication: Dysfunctional LAT2 Amino Acid Transporter Is Associated With Cataract in Mouse and Humans
Dysfunctional LAT2 Amino Acid Transporter Is Associated With Cataract in Mouse and Humans
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Boiadjieva Knöpfel, E., Vilches, C., Camargo, S. M. R., Errasti-Murugarren, E., Stäubli, A., Mayayo, C., Munier, F. L., Miroshnikova, N., Poncet, N., Junza, A., Bhattacharya, S. S., Prat, E., Berry, V., Berger, W., Heon, E., Moore, A. T., Yanes, Ó., Nunes, V., Palacín, M., … Kloeckener-Gruissem, B. (2019). Dysfunctional LAT2 Amino Acid Transporter Is Associated With Cataract in Mouse and Humans. Frontiers in Physiology, 10, 688. https://doi.org/10.3389/fphys.2019.00688
Abstract
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Abstract
Cataract, the loss of ocular lens transparency, accounts for ∼50% of worldwide blindness and has been associated with water and solute transport dysfunction across lens cellular barriers. We show that neutral amino acid antiporter LAT2 ) and uniporter TAT1 () are expressed on mouse ciliary epithelium and LAT2 also in lens epithelium. Correspondingly, deletion of LAT2 induced a dramatic decrease in lens essential amino acid levels that was modulated by TAT1 defect. Interestingly, the absence of LAT2 led to increased incidence of catara
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Creators (Authors)
- Boiadjieva Knöpfel, Emilia
- Vilches, Clara
- Camargo, Simone M R
- Errasti-Murugarren, Ekaitz
- Stäubli, Andrina
- Mayayo, Clara
- Munier, Francis L
- Miroshnikova, Nataliya
- Poncet, Nadège
- Junza, Alexandra
- Bhattacharya, Shomi S
- Prat, Esther
- Berry, Vanita
- Berger, Wolfgang
- Heon, Elise
- Moore, Anthony T
- Yanes, Óscar
- Nunes, Virginia
- Palacín, Manuel
- Verrey, Francois
- Kloeckener-Gruissem, Barbara
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Boiadjieva Knöpfel, E., Vilches, C., Camargo, S. M. R., Errasti-Murugarren, E., Stäubli, A., Mayayo, C., Munier, F. L., Miroshnikova, N., Poncet, N., Junza, A., Bhattacharya, S. S., Prat, E., Berry, V., Berger, W., Heon, E., Moore, A. T., Yanes, Ó., Nunes, V., Palacín, M., … Kloeckener-Gruissem, B. (2019). Dysfunctional LAT2 Amino Acid Transporter Is Associated With Cataract in Mouse and Humans. Frontiers in Physiology, 10, 688. https://doi.org/10.3389/fphys.2019.00688
